Hard clinical questions, grounded answers.
Real examples of Kira handling differential diagnosis, structured comparisons, screener interpretation, and multi-step clinical reasoning — each answer grounded in the knowledge base with source citations.
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Watch pre-recorded sessions animate in real time — tool orchestration, structured outputs, and sub-3s response times on complex clinical queries.
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Five hard questions that showcase the full pipeline.
Each example shows the user query, Kira's response, pipeline activity, and the tools used. Click any example to expand the full answer.
Pipeline activity
search_knowledge_base — Searched 'BPD bipolar differential diagnosis'
8 relevant chunks retrieved
compare_conditions — Built structured comparison
7-dimension comparison table generated
suggest_screeners — Identified relevant instruments
MDQ, SCID-II, MSI-BPD suggested
| Dimension | BPD | Bipolar Disorder |
|---|---|---|
| Mood shifts | Reactive, hours–days, interpersonally triggered | Autonomous, weeks–months, with distinct phases |
| Sleep | Insomnia from emotional distress | Genuinely decreased need (feels rested) |
| Identity | Chronic instability, emptiness | Relatively stable between episodes |
| Relationships | Intense, idealization-devaluation | Disrupted mainly during episodes |
| Self-harm | Chronic, regulatory function | Episodic, linked to depression |
| Onset pattern | Adolescence, stable course | Episodic with remission periods |
| Treatment | DBT, schema therapy | Mood stabilizers, lithium |
Kira's response
The distinction between borderline personality disorder (BPD) and bipolar disorder is one of the most clinically challenging differentials in psychiatry, partly because comorbidity rates run as high as 20%.
Mood instability pattern is the most reliable distinguishing feature. BPD mood shifts are reactive — triggered by interpersonal events, lasting hours to days, and revolving around abandonment, rejection, or perceived slights. Bipolar mood episodes are more autonomous, lasting weeks to months, with distinct manic/hypomanic phases that include decreased need for sleep, grandiosity, and pressured speech.
Identity disturbance is core to BPD but not characteristic of bipolar disorder. People with BPD describe chronic emptiness, shifting self-image, and unstable goals. In bipolar disorder, identity remains relatively stable between episodes.
Interpersonal patterns differ markedly. BPD involves intense, unstable relationships with idealization-devaluation cycling. Bipolar disorder doesn't typically produce this relational pattern outside of acute episodes.
Sleep architecture provides a useful biological marker. Bipolar mania involves genuinely decreased need for sleep (feeling rested after 3-4 hours). BPD may involve insomnia driven by emotional distress, but without the energized quality of mania.
Self-harm context also differs. In BPD, self-harm is often chronic, repetitive, and used for emotion regulation. In bipolar disorder, self-harm is more episodic and linked to depressive phases.
Every answer follows the same 8-stage pipeline.
No hallucination shortcuts. Each query triggers synonym expansion, dual-path hybrid search, cross-encoder reranking, agentic tool selection, and constitutional safety — all measured with bootstrap confidence intervals.
Full architecture breakdownQuery classification
Route greetings, safety, clinical
Synonym expansion
80+ clinical mappings
Hybrid search
60% vector + 40% BM25
Cross-encoder rerank
20 candidates → 8 results
Agentic tool loop
Up to 3 rounds, 4 tools
LLM generation
70B parameter model
Constitutional safety
Output guard + scope check
SSE streaming
Sources + follow-ups
Ask Kira something hard.
Differential diagnosis, pharmacology comparisons, screener interpretation, comorbidity patterns — the harder the question, the more the pipeline shines.